Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 2/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9614031 | 0.83 | KMT2A (0.52) | KMT2AMEN1MCL1SLC6A2SLC6A4 | |
| SCHEMBL9291964 | 0.82 | KCNH2 (0.41) | UTS2RKMT2ALMNAHTTNPSR1 | |
| Oxalic Acid SCHEMBL9518841 | 0.79 | MEN1 (0.38) | SCN4AUTS2RKMT2ALMNAHTT | |
| Oxalic Acid SCHEMBL9518835 | 0.79 | MEN1 (0.38) | SCN4AUTS2RKMT2ALMNAHTT | |
| Oxalic Acid SCHEMBL9613804 | 0.74 | KMT2A (0.60) | KMT2AMEN1MCL1 | |
| Oxalic Acid SCHEMBL9614065 | 0.72 | KMT2A (0.53) | KMT2AMEN1MAPTMCL1 | |
| SCHEMBL9613755 | 0.70 | KCNH2 (0.39) | KMT2ANPSR1MEN1MAPTSMN1; SMN2 | |
| Oxalic Acid SCHEMBL9613778 | 0.70 | KMT2A (0.53) | KMT2AMEN1MCL1SLC6A2SLC6A4 | |
| Oxalic Acid SCHEMBL9613947 | 0.69 | KMT2A (0.49) | KMT2AMEN1MCL1 | |
| Oxalic Acid SCHEMBL9613796 | 0.68 | KMT2A (0.51) | UTS2RKMT2AMEN1MCL1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135947-A | Treatment of depression, eating disorders, and alcoholism | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0288188-B1 | 1-PHENYL-3-NAPHTHALENYLOXY-PROPANAMINES | ELI LILLY AND COMPANY (US) | 1991-10-16 | — | — | EP | disclosed |
| EP-0288188-A1 | 1-Phenyl-3-naphthalenyloxy-propanamines | ELI LILLY AND COMPANY (US) | 1988-10-26 | — | — | EP | disclosed |