Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9292212 | 1.00 | POLB (0.50) | POLBALDH1A1RECQLSMN1; SMN2HIF1A | |
| SCHEMBL9424763 | 0.83 | POLB (0.46) | POLBALDH1A1RECQLSMN1; SMN2HIF1A | |
| SCHEMBL11252091 | 0.80 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2KMT2AMAPTMAPK1 | |
| SCHEMBL11252094 | 0.80 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2KMT2AMAPTMAPK1 | |
| SCHEMBL11255189 | 0.80 | POLB (0.56) | POLBALDH1A1RECQLSMN1; SMN2HIF1A | |
| SCHEMBL7621786 | 0.80 | POLB (0.56) | POLBALDH1A1RECQLSMN1; SMN2HIF1A | |
| SCHEMBL7621795 | 0.80 | POLB (0.56) | POLBALDH1A1RECQLSMN1; SMN2HIF1A | |
| SCHEMBL8848886 | 0.79 | PLA2G7 (0.47) | POLBALDH1A1SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL8441573 | 0.79 | PLA2G7 (0.47) | POLBALDH1A1SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL13019925 | 0.76 | PKM (0.54) | ALDH1A1SMN1; SMN2KMT2AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546005-A1 | 1,2,5,6-TETRAHYDROPYRIDINE OXIME DERIVATIVES | BEECHAM GROUP plc (GB) | 1993-06-16 | — | — | EP | claimed |
| WO-1992004323-A1 | 1,2,5,6-TETRAHYDROPYRIDINE OXIME DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-03-19 | — | — | WO | claimed |
| US-5356914-A | Cognition activators | BEECHAM GROUP P.L.C. (GB) | 1994-10-18 | — | — | US | disclosed |
| US-5314901-A | 1,2,5,6-tetrahydropyridine oxime compounds | BEECHAM GROUP P.L.C. (GB) | 1994-05-24 | — | — | US | disclosed |
| EP-0546005-A1 | 1,2,5,6-TETRAHYDROPYRIDINE OXIME DERIVATIVES | BEECHAM GROUP plc (GB) | 1993-06-16 | — | — | EP | disclosed |
| WO-1992006959-A1 | 1,2,5,6-TETRAHYDROPYRIDINE OXIME DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-04-30 | — | — | WO | disclosed |
| WO-1992004323-A1 | 1,2,5,6-TETRAHYDROPYRIDINE OXIME DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-03-19 | — | — | WO | disclosed |