SCHEMBL9293223

SCHEMBL9293223

O=C1CCCN1Cc1ccc(O)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.65
HRH3 Q9Y5N1 1/20 0.59
ACACB O00763 1/20 0.54
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
GRIA2 P42262 1/20 0.47
WDR91 A4D1P6 2/20 0.46
LTA4H P09960 1/20 0.46
KMT2A Q03164 2/20 0.46
KCNH2 Q12809 1/20 0.45
CDC7 O00311 1/20 0.45
PLK4 O00444 1/20 0.45
AURKA O14965 1/20 0.45
MAPK13 O15264 1/20 0.45
PDPK1 O15530 1/20 0.45
DYRK3 O43781 1/20 0.45
PRKD3 O94806 1/20 0.45
MAP4K4 O95819 1/20 0.45
PAK4 O96013 1/20 0.45
ERBB2 P04626 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11759154 0.95 L3MBTL1 (0.73) L3MBTL1HRH3ACACBCYP1A2CYP2C9
SCHEMBL11200681 0.91 L3MBTL1 (0.76) L3MBTL1HRH3ACACBCYP1A2CYP2C9
SCHEMBL13853398 0.86 L3MBTL1 (0.65) L3MBTL1HRH3ACACBCYP1A2CYP2C9
SCHEMBL10399987 0.84 L3MBTL1 (0.67) L3MBTL1HRH3ACACBCYP1A2CYP2C9
SCHEMBL19717008 0.84 L3MBTL1 (0.67) L3MBTL1HRH3ACACBCYP1A2CYP2C9
SCHEMBL2774412 0.83 L3MBTL1 (0.66) L3MBTL1HRH3ACACBWDR91KMT2A
SCHEMBL256037 0.82 L3MBTL1 (0.65) L3MBTL1HRH3ACACBCYP1A2CYP2C9
SCHEMBL6824717 0.82 L3MBTL1 (0.65) L3MBTL1HRH3ACACBCYP1A2CYP2C9
SCHEMBL5578262 0.82 L3MBTL1 (0.65) L3MBTL1HRH3ACACBCYP1A2CYP2C9
SCHEMBL632892 0.82 L3MBTL1 (0.65) L3MBTL1HRH3ACACBCYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5124444-A LACTAM-CONTAINING COMPOSITIONS AND METHODS USEFUL FOR THE EXTRACTION OF NUCLEIC ACIDS MICROPROBE CORPORATION (US) 1992-06-23 US claimed
US-5106730-A Lactam-containing compositions and methods useful for the hybridization of nucleic acids MICROPROBE CORPORATION (US) 1992-04-21 US claimed
WO-1991002088-A1 LACTAM-CONTAINING COMPOSITIONS AND METHODS USEFUL FOR THE HYBRIDIZATION OF NUCLEIC ACIDS MICROPROBE CORPORATION (US) 1991-02-21 WO claimed
WO-1991002089-A1 LACTAM-CONTAINING COMPOSITIONS AND METHODS USEFUL FOR THE EXTRACTION OF NUCLEIC ACIDS MICROPROBE CORPORATION (US) 1991-02-21 WO claimed
EP-0005143-A1 1-Benzoyl-2-pyrrolidinone derivative, processes for its preparation and medicaments containing it F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1979-11-14 EP claimed
US-20090137577-A1 HETEROCYCLIC COMPOUNDS PFIZER INC. 2009-05-28 US disclosed
US-5376529-A Lactam-containing compositions and methods useful for the hybridization of nucleic acids MICROPROBE CORPORATION (US) 1994-12-27 US disclosed
US-5376529-A Lactam-containing compositions and methods useful for the hybridization of nucleic acids MICROPROBE CORPORATION (US) 1994-12-27 US disclosed
US-5124444-A LACTAM-CONTAINING COMPOSITIONS AND METHODS USEFUL FOR THE EXTRACTION OF NUCLEIC ACIDS MICROPROBE CORPORATION (US) 1992-06-23 US disclosed
US-5124444-A LACTAM-CONTAINING COMPOSITIONS AND METHODS USEFUL FOR THE EXTRACTION OF NUCLEIC ACIDS MICROPROBE CORPORATION (US) 1992-06-23 US disclosed
US-5106730-A Lactam-containing compositions and methods useful for the hybridization of nucleic acids MICROPROBE CORPORATION (US) 1992-04-21 US disclosed
US-5106730-A Lactam-containing compositions and methods useful for the hybridization of nucleic acids MICROPROBE CORPORATION (US) 1992-04-21 US disclosed
WO-1991002088-A1 LACTAM-CONTAINING COMPOSITIONS AND METHODS USEFUL FOR THE HYBRIDIZATION OF NUCLEIC ACIDS MICROPROBE CORPORATION (US) 1991-02-21 WO disclosed
WO-1991002089-A1 LACTAM-CONTAINING COMPOSITIONS AND METHODS USEFUL FOR THE EXTRACTION OF NUCLEIC ACIDS MICROPROBE CORPORATION (US) 1991-02-21 WO disclosed
WO-1991002089-A1 LACTAM-CONTAINING COMPOSITIONS AND METHODS USEFUL FOR THE EXTRACTION OF NUCLEIC ACIDS MICROPROBE CORPORATION (US) 1991-02-21 WO disclosed
WO-1991002088-A1 LACTAM-CONTAINING COMPOSITIONS AND METHODS USEFUL FOR THE HYBRIDIZATION OF NUCLEIC ACIDS MICROPROBE CORPORATION (US) 1991-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137577-A1 HETEROCYCLIC COMPOUNDS CYP2D6, ABCG2, CYP2B6 L3MBTL1 4751/4885HRH3 1409/4885ACACB 416/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.