Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 11/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | NPC1 | O15118 | 4/20 | 0.66 |
| ▸ | RAB9A | P51151 | 4/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24265732 | 0.95 | LMNA (0.69) | WDR5LMNANPC1RAB9AHTT | |
| SCHEMBL4839735 | 0.80 | WDR5 (0.71) | WDR5LMNANPC1RAB9AHTT | |
| SCHEMBL989261 | 0.79 | WDR5 (1.00) | WDR5LMNANPC1RAB9AHTT | |
| SCHEMBL9199162 | 0.79 | WDR5 (1.00) | WDR5LMNANPC1RAB9AHTT | |
| SCHEMBL9700032 | 0.78 | WDR5 (0.73) | WDR5LMNANPC1RAB9AHTT | |
| SCHEMBL18281469 | 0.77 | LMNA (0.94) | WDR5LMNANPC1RAB9AHTT | |
| Bromide SCHEMBL9839171 | 0.76 | WDR5 (0.71) | WDR5LMNANPC1RAB9AHTT | |
| Hydrochloric Acid SCHEMBL5300777 | 0.76 | LMNA (0.97) | WDR5LMNANPC1RAB9AHTT | |
| SCHEMBL10749027 | 0.75 | LMNA (0.48) | WDR5LMNANPC1RAB9AHTT | |
| SCHEMBL9698908 | 0.75 | LMNA (0.70) | WDR5LMNANPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533837-A4 | INHIBITION OF 5-LIPOXYGENASE AND CYCLOOXYGENASE PATHWAY MEDIATED DISEASES | SMITHKLINE BEECHAM CORP (US) | 1994-11-17 | — | — | EP | disclosed |
| EP-0533837-A1 | INHIBITION OF 5-LIPOXYGENASE AND CYCLOOXYGENASE PATHWAY MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991019497-A1 | INHIBITION OF 5-LIPOXYGENASE AND CYCLOOXYGENASE PATHWAY MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |