Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24872393 | 0.81 | CYP1A2 (0.44) | BRD4DRD1HRH2HTR2AHTR2C | |
| SCHEMBL92931 | 0.79 | KMT2A (0.30) | — | |
| SCHEMBL13968227 | 0.78 | FFAR1 (0.38) | POLBOPRD1 | |
| SCHEMBL3035722 | 0.78 | L3MBTL1 (0.38) | POLBFKBP1AKDM4EALDH1A1 | |
| SCHEMBL12606506 | 0.78 | CHRM2 (0.41) | POLBFKBP1A | |
| SCHEMBL1779547 | 0.78 | L3MBTL1 (0.38) | POLBFKBP1AKDM4EALDH1A1 | |
| SCHEMBL11990444 | 0.76 | EPHX2 (0.33) | EPHX2BRD4SMN1; SMN2DRD1HRH2 | |
| SCHEMBL11990399 | 0.76 | EPHX2 (0.33) | EPHX2BRD4SMN1; SMN2DRD1HRH2 | |
| SCHEMBL19349848 | 0.76 | SMN1; SMN2 (0.44) | EPHX2BRD4SMN1; SMN2OPRD1ALDH1A1 | |
| SCHEMBL25346172 | 0.76 | CTSK (0.46) | EPHX2POLBBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129384-B2 | Imidazo[1,2-a]pyrazines as orexin receptor antagonists | GLAXO GROUP LIMITED (GB) | 2012-03-06 | — | — | US | disclosed |
| US-20110288098-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED | 2011-11-24 | — | — | US | disclosed |
| US-20100267730-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-10-21 | — | — | US | disclosed |
| US-20100160345-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-06-24 | — | — | US | disclosed |
| US-20090022670-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288098-A1 | NOVEL COMPOUNDS | BRD4, HDAC6, ITPR3 | EPHX2 3560/4885POLB 3898/4885BRD4 1/4885 |
| US-20090022670-A1 | NOVEL COMPOUNDS | UGT1A1, UGT2B7, ABCB1 | EPHX2 3754/4885POLB 1998/4885BRD4 151/4885 |
| US-20100267730-A1 | NOVEL COMPOUNDS | BRD4, DPP4, ITPR3 | EPHX2 3934/4885POLB 4071/4885BRD4 1/4885 |
| US-20100160345-A1 | NOVEL COMPOUNDS | BRD4, HDAC6, ITPR3 | EPHX2 3560/4885POLB 3898/4885BRD4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.