Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 4/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9293238 | 0.91 | CHRM2 (0.37) | ALDH1A1GAACHRM2CHRM1MEN1 | |
| SCHEMBL8935510 | 0.78 | CHRNA7 (0.45) | ALDH1A1GAACHRNA7CHRM2CHRM1 | |
| SCHEMBL15341643 | 0.78 | ALDH1A1 (0.46) | ALDH1A1GAACHRNA7CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL8935476 | 0.77 | ALDH1A1 (0.45) | ALDH1A1GAACHRNA7CHRM2CHRM1 | |
| SCHEMBL28273440 | 0.74 | ALDH1A1 (0.49) | ALDH1A1GAACHRNA7CHRM2CHRM1 | |
| SCHEMBL8935442 | 0.74 | ALDH1A1 (0.40) | ALDH1A1GAACHRNA7CHRM2CHRM1 | |
| SCHEMBL2495325 | 0.73 | ALDH1A1 (0.51) | ALDH1A1GAACHRNA7CHRM2CHRM1 | |
| SCHEMBL5171234 | 0.73 | ALDH1A1 (0.51) | ALDH1A1GAACHRNA7CHRM2CHRM1 | |
| SCHEMBL1617171 | 0.73 | ALDH1A1 (0.51) | ALDH1A1GAACHRNA7CHRM2CHRM1 | |
| SCHEMBL8935448 | 0.72 | CHRM2 (0.41) | ALDH1A1GAACHRM2CHRM1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5324724-A | Azabicyclic compounds; Alzheimer's disease treatment | BEECHAM GROUP P.L.C. (GB) | 1994-06-28 | — | — | US | disclosed |
| EP-0594605-A1 | 1-AZABICYCLIC COMPOUNDS, PROCESSES AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM | Beecham Group p.l.c. (GB) | 1994-05-04 | — | — | EP | disclosed |
| US-5166357-A | Nitrogen heterocylic compounds used in treatment of dementia in mammals | BEECHAM GROUP P.L.C. (GB) | 1992-11-24 | — | — | US | disclosed |
| WO-1991013885-A1 | 1-AZABICYCLIC COMPOUNDS, PROCESSES AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1991-09-19 | — | — | WO | disclosed |
| EP-0366304-A2 | Heterocyclic derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1990-05-02 | — | — | EP | disclosed |