Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9293836 | 0.91 | ALDH1A1 (0.41) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| SCHEMBL9523751 | 0.79 | CHRM2 (0.41) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8935473 | 0.78 | PEPD (0.43) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| Bromide SCHEMBL9298859 | 0.76 | CHRM2 (0.41) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| Bromide SCHEMBL2424119 | 0.76 | CHRM2 (0.41) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| SCHEMBL7913837 | 0.75 | CHRM1 (0.45) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| SCHEMBL8935481 | 0.75 | CHRM2 (0.36) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| SCHEMBL4339192 | 0.74 | CHRM2 (0.42) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| SCHEMBL7493133 | 0.74 | CHRM2 (0.42) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| SCHEMBL4762996 | 0.74 | CHRM2 (0.42) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5324724-A | Azabicyclic compounds; Alzheimer's disease treatment | BEECHAM GROUP P.L.C. (GB) | 1994-06-28 | — | — | US | disclosed |
| EP-0594605-A1 | 1-AZABICYCLIC COMPOUNDS, PROCESSES AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM | Beecham Group p.l.c. (GB) | 1994-05-04 | — | — | EP | disclosed |
| US-5166357-A | Nitrogen heterocylic compounds used in treatment of dementia in mammals | BEECHAM GROUP P.L.C. (GB) | 1992-11-24 | — | — | US | disclosed |
| WO-1991013885-A1 | 1-AZABICYCLIC COMPOUNDS, PROCESSES AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1991-09-19 | — | — | WO | disclosed |
| EP-0366304-A2 | Heterocyclic derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1990-05-02 | — | — | EP | disclosed |