Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20582829 | 0.84 | RPS6KA3 (0.47) | RPS6KA3MAPTNPC1RAB9AKDM4E | |
| SCHEMBL8570282 | 0.82 | NPSR1 (0.37) | RPS6KA3MAPTNPC1RAB9AKDM4E | |
| SCHEMBL9860043 | 0.80 | KDM4E (0.38) | RPS6KA3MAPTNPC1RAB9AKDM4E | |
| SCHEMBL3078639 | 0.78 | MAPT (0.42) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL3087121 | 0.77 | ALDH1A1 (0.39) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL2602613 | 0.74 | MAPT (0.40) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL13094307 | 0.73 | ALDH1A1 (0.39) | RPS6KA3MAPTNPC1RAB9AKDM4E | |
| SCHEMBL457151 | 0.73 | TRPA1 (0.50) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL1002641 | 0.73 | KDM4E (0.39) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL3708636 | 0.72 | TRPA1 (0.46) | MAPTKDM4EALDH1A1TDP1TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12162871-B2 | Inhibitors of VAP-1 | ACUCELA INC. (US) | 2024-12-10 | — | — | US | disclosed |
| US-11787791-B2 | Inhibitors of VAP-1 | ACUCELA INC. (US) | 2023-10-17 | — | — | US | disclosed |
| US-20230295140-A1 | INHIBITORS OF VAP-1 | ACUCELA INC. | 2023-09-21 | — | — | US | disclosed |
| US-20210387975-A1 | INHIBITORS OF VAP-1 | ACUCELA INC. | 2021-12-16 | — | — | US | disclosed |
| EP-3856176-A2 | INHIBITORS OF VAP-1 | Acucela Inc. (US) | 2021-08-04 | — | — | EP | disclosed |
| CN-113164454-A | Inhibitors of VAP-1 | 奥克塞拉有限公司 | 2021-07-23 | — | — | CN | disclosed |
| WO-2020069330-A2 | INHIBITORS OF VAP-1 | ACUCELA INC. (US) | 2020-04-02 | — | — | WO | disclosed |
| CN-108473788-A | Disazo colorants for use as bluing agents | 美利肯公司 | 2018-08-31 | — | — | CN | disclosed |
| WO-2012024394-A2 | COMPOSITIONS COMPRISING PAULOWNIN AND/OR PAULOWNIA EXTRACTS AND USES THEREOF | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) | 2012-02-23 | — | — | WO | disclosed |
| WO-2012024403-A2 | METHODS OF TREATING CELLULITE | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) | 2012-02-23 | — | — | WO | disclosed |
| EP-0156347-B1 | GLYCOSIDES OF RESOFURIN DERIVATIVES, METHOD FOR THEIR PREPARATION AND THEIR USE IN THE DETERMINATION OF THE ACTIVITY OF GLYCOSIDASES | Roche Diagnostics GmbH (DE) | 1991-09-04 | — | — | EP | disclosed |
| US-4988497-A | Diagnostic test for acute pancreatitus or cancer of the pancreas; sensitivity; colorimetry S | BOEHRINGER MANNHEIM GMBH (DE) | 1991-01-29 | — | — | US | disclosed |
| US-4954630-A | COLORIMETRIC OR FLUORESCENT ANALYSIS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-09-04 | — | — | US | disclosed |
| EP-0209875-B1 | RESORUFIN DERIVATIVES AND PROCESS FOR THEIR PREPARATION | Roche Diagnostics GmbH (DE) | 1990-08-29 | — | — | EP | disclosed |
| US-4847376-A | COLORIMETRIC ANALYSIS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-11 | — | — | US | disclosed |
| US-4737466-A | N-acyldihydroresorufin derivatives, processes for their preparation, reagents containing them and the use thereof for determining hydrogen peroxide, peroxidate-acting compounds or peroxidase | BOEHRINGER MANNHEIM GMBH (DE) | 1988-04-12 | — | — | US | disclosed |
| US-4719097-A | Phosphates of resorufin derivatives and compositions thereof for the determination of the activity of phosphatases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-01-12 | — | — | US | disclosed |
| EP-0210559-A2 | N-Acyldihydroresorufin derivatives, process for their preparation as well as their use for the determination of hydrogen peroxide, peroxidatically active compounds, or peroxidase | Roche Diagnostics GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |
| EP-0209875-A1 | Resorufin derivatives and process for their preparation | Roche Diagnostics GmbH (DE) | 1987-01-28 | — | — | EP | disclosed |
| EP-0207252-A2 | Aromatic hydroxy- or thiol derivatives of carbonic-acid esters as lipase substrates | Roche Diagnostics GmbH (DE) | 1987-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787791-B2 | Inhibitors of VAP-1 | VAPB, VAPA, TOE1 | RPS6KA3 2802/4885MAPT 2213/4885NPC1 198/4885 |
| US-20230295140-A1 | INHIBITORS OF VAP-1 | VAPB, VAPA, TOE1 | RPS6KA3 2802/4885MAPT 2213/4885NPC1 198/4885 |
| US-20210387975-A1 | INHIBITORS OF VAP-1 | VAPB, VAPA, TOE1 | RPS6KA3 2802/4885MAPT 2213/4885NPC1 198/4885 |
| US-12162871-B2 | Inhibitors of VAP-1 | VAPB, VAPA, TOE1 | RPS6KA3 2802/4885MAPT 2213/4885NPC1 198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.