SCHEMBL929697

SCHEMBL929697

CC(Cl)Oc1cccc(Br)c1

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MITF O75030 1/20 0.45
HSD17B10 Q99714 1/20 0.44
MAOB P27338 8/20 0.43
ALDH1A1 P00352 4/20 0.42
KDM4E B2RXH2 3/20 0.42
MAPT P10636 2/20 0.41
CYP1A2 P05177 1/20 0.41
GAA P10253 1/20 0.41
RECQL P46063 1/20 0.41
LMNA P02545 1/20 0.41
KMT2A Q03164 2/20 0.40
MAPK1 P28482 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1204347 0.83 NPC1 (0.49) MITFHSD17B10MAOBALDH1A1KDM4E
SCHEMBL29731196 0.83 NPC1 (0.49) MITFHSD17B10MAOBALDH1A1KDM4E
SCHEMBL8384042 0.83 NPC1 (0.49) MITFHSD17B10MAOBALDH1A1KDM4E
SCHEMBL4093572 0.82 HSD17B10 (0.45) MITFHSD17B10MAOBALDH1A1KDM4E
SCHEMBL1222745 0.82 LMNA (0.48) MITFHSD17B10MAOBALDH1A1KDM4E
SCHEMBL11582759 0.80 HSD17B10 (0.44) MITFHSD17B10MAOBALDH1A1KDM4E
SCHEMBL5830779 0.78 HSD17B10 (0.47) MITFHSD17B10MAOBALDH1A1KDM4E
SCHEMBL3702211 0.78 HSD17B10 (0.43) MITFHSD17B10MAOBALDH1A1KDM4E
SCHEMBL7759144 0.78 NCEH1 (0.49) ALDH1A1KDM4EMAPTCYP1A2LMNA
SCHEMBL10451483 0.78 OGG1 (0.56) ALDH1A1KDM4EMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2448941-A2 PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS Genentech, Inc. (US) 2012-05-09 EP disclosed
WO-2011003065-A2 PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS GENENTECH, INC. (US) 2011-01-06 WO disclosed
EP-1140896-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 Takeda Chemical Industries, Ltd. (JP) 2001-10-10 EP disclosed
WO-2000037455-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-06-29 WO disclosed