Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | TYK2 | P29597 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | NT5E | P21589 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10020286 | 0.80 | MDM2 (1.00) | MDM2KDM4EL3MBTL1TAAR1GAA | |
| SCHEMBL1234281 | 0.78 | MDM2 (0.70) | MDM2KDM4EL3MBTL1TAAR1GAA | |
| SCHEMBL6061912 | 0.78 | MDM2 (0.70) | MDM2KDM4EL3MBTL1TAAR1GAA | |
| SCHEMBL31668740 | 0.78 | MDM2 (0.95) | MDM2KDM4EL3MBTL1TAAR1GAA | |
| SCHEMBL5633200 | 0.77 | MDM2 (0.75) | MDM2KDM4EL3MBTL1TAAR1GAA | |
| SCHEMBL5417314 | 0.76 | MDM2 (0.67) | MDM2KDM4EL3MBTL1TAAR1GAA | |
| SCHEMBL230957 | 0.76 | MDM2 (0.67) | MDM2KDM4EL3MBTL1TAAR1GAA | |
| SCHEMBL48610 | 0.76 | TSHR (0.69) | MDM2KDM4EL3MBTL1TAAR1GAA | |
| SCHEMBL232764 | 0.76 | MDM2 (0.67) | MDM2KDM4EL3MBTL1TAAR1GAA | |
| SCHEMBL1703485 | 0.76 | MDM2 (0.54) | MDM2KDM4EL3MBTL1TAAR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278169-A | Method of treating or prevention of fibrillation of the heart | E. R. SQUIBB & SONS, INC. (US) | 1994-01-11 | — | — | US | disclosed |
| US-5011837-A | Aryl cyanoguanidines: potassium channel activators and method of making same | E. R. SQUIBB & SONS, INC. (US) | 1991-04-30 | — | — | US | disclosed |
| EP-0354553-A2 | Aryl cyanoguanidines: potassium channel activators and method of making same | E.R. SQUIBB & SONS, INC. (US) | 1990-02-14 | — | — | EP | disclosed |