Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | TYK2 | P29597 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL222140 | 0.76 | MDM2 (0.54) | MDM2KDM4EL3MBTL1TAAR1CTSD | |
| SCHEMBL160867 | 0.76 | MDM2 (0.54) | MDM2KDM4EL3MBTL1TAAR1CTSD | |
| SCHEMBL9297607 | 0.76 | MDM2 (0.67) | MDM2KDM4EL3MBTL1TAAR1KMT2A | |
| Phenylthiourea SCHEMBL1387782 | 0.75 | HSD17B10 (0.50) | CTSDKMT2AMEN1GAAEPHX1 | |
| Hydrochloric Acid SCHEMBL11099750 | 0.74 | MDM2 (0.52) | MDM2KDM4EL3MBTL1TAAR1CTSD | |
| SCHEMBL4629194 | 0.74 | RAB9A (0.55) | KDM4EKMT2AMEN1ALDH1A1 | |
| Phenylthiourea SCHEMBL1286887 | 0.73 | HSD17B10 (0.48) | CTSDKMT2AMEN1GAAEPHX1 | |
| SCHEMBL27685296 | 0.73 | GAA (0.52) | KDM4EL3MBTL1KMT2AMEN1GAA | |
| Phenylthiourea SCHEMBL4752639 | 0.73 | HSD17B10 (0.48) | CTSDKMT2AMEN1GAAEPHX1 | |
| SCHEMBL232764 | 0.71 | MDM2 (0.67) | MDM2KDM4EL3MBTL1TAAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102639503-B | Pyridinyl derivatives as inhibitors of enzyme nicotinamide phosphoribosyltransferase | TOPOTARGET A/S (DK) | 2014-10-15 | — | — | CN | disclosed |
| CN-102639503-A | Pyridinyl derivatives as inhibitors of enzyme nicotinamide phosphoribosyltransferase | TOPOTARGET AS | 2012-08-15 | — | — | CN | disclosed |
| EP-2440527-A1 | PYRIDINYL DERIVATIVES AS INHIBITORS OF ENZYME NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | Topo Target A/S (DK) | 2012-04-18 | — | — | EP | disclosed |
| WO-2011121055-A1 | PYRIDINYL DERIVATIVES COMPRISING A CYANOGUANIDINE OR SQUARIC ACID MOIETY | TOPOTARGET A/S (DK) | 2011-10-06 | — | — | WO | disclosed |
| WO-2010142735-A1 | PYRIDINYL DERIVATIVES AS INHIBITORS OF ENZYME NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | TOPOTARGET A/S (DK) | 2010-12-16 | — | — | WO | disclosed |
| WO-2009086835-A1 | NOVEL CYANOGUANIDINES | TOPOTARGET A/S (DK) | 2009-07-16 | — | — | WO | disclosed |
| CN-1247570-C | Novel pyridyl cyanoguandine compounds | LEO PHARMA AS (DK) | 2006-03-29 | — | — | CN | disclosed |
| CN-1509283-A | novel pyridyl cyanoguanidine compounds | ������ҩ������˾ | 2004-06-30 | — | — | CN | disclosed |
| EP-1397355-A1 | PYRIDYL CYANOGUANIDINE COMPOUNDS | Leo Pharma A/S (DK) | 2004-03-17 | — | — | EP | disclosed |
| CN-1121389-C | Cyanoguanidine as cell proliferation inhibitor | LEO PHARM PROD LTD (DK) | 2003-09-17 | — | — | CN | disclosed |
| CN-1116283-C | Cyanoguanidines as cell proliferation inhibitors | LEO PHARM PROD LTD (DK) | 2003-07-30 | — | — | CN | disclosed |
| WO-2002094813-A1 | NOVEL PYRIDYL CYANOGUANIDINE COMPOUNDS | LEO PHARMA A/S (DK) | 2002-11-28 | — | — | WO | disclosed |
| CN-1258276-A | Cyanoguanidines as cell proliferation inhibitors | LEO PHARM PROD LTD (DK) | 2000-06-28 | — | — | CN | disclosed |
| CN-1258277-A | Cyanoguanidines as cell proliferation inhibitors | LEO PHARM PROD LTD (DK) | 2000-06-28 | — | — | CN | disclosed |
| CN-1258279-A | Cyanoguanidines as cell proliferation inhibitors | LEO PHARM PROD LTD (DK) | 2000-06-28 | — | — | CN | disclosed |
| CN-1258278-A | Cyanoguanidines as cell proliferation inhibitors | LEO PHARM PROD LTD (DK) | 2000-06-28 | — | — | CN | disclosed |
| EP-0984936-A1 | CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998054141-A1 | CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1998-12-03 | — | — | WO | disclosed |
| WO-1998054142-A1 | CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1998-12-03 | — | — | WO | disclosed |