Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.75 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | MEN1 | O00255 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.53 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10020286 | 0.86 | MDM2 (1.00) | MDM2TAAR1KMT2AMEN1KDM4E | |
| SCHEMBL31668740 | 0.84 | MDM2 (0.95) | MDM2TAAR1KMT2AMEN1KDM4E | |
| SCHEMBL305498 | 0.78 | TAAR1 (1.00) | MDM2TAAR1KMT2AMEN1RAB9A | |
| SCHEMBL8666001 | 0.78 | MDM2 (0.75) | MDM2TAAR1KMT2AMEN1KDM4E | |
| SCHEMBL7789976 | 0.78 | MDM2 (0.75) | MDM2TAAR1KMT2AMEN1KDM4E | |
| SCHEMBL23999548 | 0.78 | MDM2 (0.83) | MDM2TAAR1KMT2AMEN1KDM4E | |
| SCHEMBL9297607 | 0.77 | MDM2 (0.67) | MDM2TAAR1KMT2AMEN1KDM4E | |
| SCHEMBL1615552 | 0.77 | SMN1; SMN2 (0.73) | TAAR1KMT2AMEN1KDM4ERAB9A | |
| SCHEMBL5633303 | 0.76 | RAB9A (0.63) | TAAR1KMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL11699912 | 0.76 | MAOA (0.63) | KMT2AMEN1KDM4EL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253197-B2 | Aminothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |