Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL779741 | 0.80 | ADRA1A (0.39) | AKR1B1ALDH1A1ADRA2AADRA1DADRA1A | |
| SCHEMBL9531758 | 0.73 | TSHR (0.40) | HDAC9ALDH1A1ADRA2AADRA1DADRA1A | |
| SCHEMBL4432306 | 0.70 | HDAC9 (0.71) | HDAC9TSHRAKR1C1KDM1A | |
| SCHEMBL14214917 | 0.70 | HDAC9 (0.57) | HDAC9AKR1B1TSHRAKR1C1MEN1 | |
| SCHEMBL4851505 | 0.69 | KDM1A (0.50) | HDAC9AKR1B1KDM5AKDM4CKDM5B | |
| SCHEMBL30219063 | 0.69 | AKR1C1 (0.48) | HDAC9AKR1B1TSHRAKR1C1MEN1 | |
| SCHEMBL687495 | 0.69 | AKR1C1 (0.48) | HDAC9AKR1B1TSHRAKR1C1MEN1 | |
| SCHEMBL28941603 | 0.68 | HDAC9 (0.43) | HDAC9AKR1B1TSHRAKR1C1CYP3A4 | |
| SCHEMBL27728415 | 0.68 | HDAC9 (0.55) | HDAC9KDM5AKDM4CKDM5BALDH1A1 | |
| SCHEMBL367096 | 0.67 | AKR1C1 (0.47) | HDAC9AKR1B1TSHRAKR1C1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354770-A | Cardiovascular system disorders | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1994-10-11 | — | — | US | disclosed |