Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531758 | 0.91 | TSHR (0.40) | ADRA1AADRA2AADRA1DADRA1BCYP3A4 | |
| SCHEMBL9298985 | 0.80 | HDAC9 (0.43) | ADRA1AADRA2AADRA1DADRA1BCYP3A4 | |
| SCHEMBL4133169 | 0.74 | CYP3A4 (0.58) | CYP3A4AKR1B1KDM1ASIGMAR1ADORA3 | |
| SCHEMBL14969273 | 0.74 | TP53 (0.33) | ADRA1AADRA2ATSHRTP53CYP11B1 | |
| SCHEMBL769157 | 0.73 | TSHR (0.40) | ADRA1AADRA2AADRA1DADRA1BCYP3A4 | |
| SCHEMBL6316631 | 0.73 | PGR (0.47) | CYP3A4TSHRMEN1CYP2D6CYP2C19 | |
| SCHEMBL768782 | 0.71 | AKR1B1 (0.40) | AKR1B1KDM1ASIGMAR1ADORA3 | |
| SCHEMBL779503 | 0.71 | ADRA2A (0.46) | ADRA2AADRA1BAKR1B1KDM1AADORA3 | |
| SCHEMBL768915 | 0.71 | TSHR (0.40) | CYP3A4TSHRMEN1CYP2D6CYP2C9 | |
| SCHEMBL779687 | 0.69 | KDM1A (0.38) | KDM1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071506-A1 | METHODS FOR TREATING CNS DISORDERS WITH BICYCLO-SUBSTITUTED 2-IMIDAZOLINE AND 2-IMIDAZOLES | GALLEY GUIDO (DE) | 2012-03-22 | — | — | US | disclosed |
| US-20070197620-A1 | Methods for treating CNS disorders with bicyclo-substituted 2-imidazoline and 2-imidazoles | HOFFMANN-LA ROCHE INC. | 2007-08-23 | — | — | US | disclosed |
| EP-0341846-B1 | AZOLE DERIVATIVES OF SPIROHETEROCYCLES | UNIROYAL CHEMICAL COMPANY, Inc. (US) | 1993-08-18 | — | — | EP | disclosed |
| US-5211736-A | Fungicide, plant growth regulator | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1993-05-18 | — | — | US | disclosed |
| US-5106409-A | Fungicides, plant growth regulators | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1992-04-21 | — | — | US | disclosed |
| US-4943311-A | Azole derivatives of spiroheterocycles | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1990-07-24 | — | — | US | disclosed |
| EP-0341846-A2 | Azole derivatives of spiroheterocycles | UNIROYAL CHEMICAL COMPANY, Inc. (US) | 1989-11-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071506-A1 | METHODS FOR TREATING CNS DISORDERS WITH BICYCLO-SUBSTITUTED 2-IMIDAZOLINE AND 2-IMIDAZOLES | CRY1, PER2, GPR119 | ADRA1A 188/4885ADRA2A 102/4885ADRA1D 66/4885 |
| US-20070197620-A1 | Methods for treating CNS disorders with bicyclo-substituted 2-imidazoline and 2-imidazoles | CRY1, PER2, GPR119 | ADRA1A 203/4885ADRA2A 106/4885ADRA1D 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.