Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9299131 | 1.00 | ALOX5 (0.39) | ALOX5PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9299692 | 0.83 | MAPT (0.43) | PDE4APDE4BPDE4CPDE4DGABRA1 | |
| SCHEMBL9299283 | 0.82 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DGABRA1 | |
| SCHEMBL9299687 | 0.81 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DCASP3 | |
| SCHEMBL9299240 | 0.80 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DCASP3 | |
| SCHEMBL9299769 | 0.80 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DGABRA1 | |
| SCHEMBL8077042 | 0.78 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL7269375 | 0.77 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DCASP3 | |
| SCHEMBL9300068 | 0.77 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL8088661 | 0.76 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296492-A | Certain chroman derivatives useful for treating symptoms caused by contraction of smooth muscles, circulatory diseases or epilepsy | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1994-03-22 | — | — | US | disclosed |
| EP-0518342-A1 | Chroman derivatives | Nippon Kayaku Kabushiki Kaisha (JP) | 1992-12-16 | — | — | EP | disclosed |