Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 6/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.31 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.31 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9299687 | 0.90 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMALT1 | |
| SCHEMBL7269375 | 0.84 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMALT1 | |
| SCHEMBL8088661 | 0.83 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMALT1 | |
| Bimakalim SCHEMBL231904 | 0.82 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DMALT1 | |
| SCHEMBL9299270 | 0.82 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DABCB1 | |
| SCHEMBL9300068 | 0.81 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMALT1 | |
| SCHEMBL9596470 | 0.81 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMALT1 | |
| SCHEMBL9299131 | 0.80 | ALOX5 (0.39) | PDE4APDE4BPDE4CPDE4DCASP3 | |
| SCHEMBL9299133 | 0.80 | ALOX5 (0.39) | PDE4APDE4BPDE4CPDE4DCASP3 | |
| SCHEMBL8090538 | 0.80 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296492-A | Certain chroman derivatives useful for treating symptoms caused by contraction of smooth muscles, circulatory diseases or epilepsy | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1994-03-22 | — | — | US | disclosed |
| EP-0518342-A1 | Chroman derivatives | Nippon Kayaku Kabushiki Kaisha (JP) | 1992-12-16 | — | — | EP | disclosed |