Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 4/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.51 |
| ▸ | GRM6 | O15303 | 3/20 | 0.50 |
| ▸ | ACP3 | P15309 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | DDX3X | O00571 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31226322 | 0.87 | GRM8 (0.53) | GRM8GRM4GRM6ACP3TSHR | |
| SCHEMBL666103 | 0.87 | GRM8 (0.53) | GRM8GRM4GRM6ACP3TSHR | |
| SCHEMBL666474 | 0.85 | GRM8 (0.49) | GRM8GRM4GRM6ACP3TSHR | |
| SCHEMBL666558 | 0.84 | GRM8 (0.54) | GRM8GRM4GRM6ACP3TSHR | |
| SCHEMBL11452596 | 0.83 | L3MBTL1 (0.59) | GRM8GRM4GRM6ACP3TSHR | |
| SCHEMBL4703596 | 0.82 | TSHR (0.53) | GRM8GRM4GRM6ACP3TSHR | |
| SCHEMBL21200058 | 0.81 | L3MBTL1 (0.58) | GRM8GRM4GRM6ACP3TSHR | |
| SCHEMBL29866906 | 0.81 | L3MBTL1 (0.58) | GRM8GRM4GRM6ACP3TSHR | |
| SCHEMBL16809247 | 0.81 | TSHR (0.52) | GRM8GRM4GRM6ACP3TSHR | |
| SCHEMBL4754819 | 0.80 | ALDH1A1 (0.50) | GRM8GRM4GRM6TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5280027-A | Quinazoline containing compound | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-18 | — | — | US | disclosed |
| EP-0459730-A2 | Anti-tumour compounds | ZENECA LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |