Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL725388 | 0.95 | CA5A (0.47) | CA5ACA5BALDH1A1KDM4ESMN1; SMN2 | |
| Trolamine SCHEMBL2396169 | 0.95 | CA5A (0.47) | CA5ACA5BALDH1A1KDM4ESMN1; SMN2 | |
| Trolamine SCHEMBL9299420 | 0.92 | CA5A (0.44) | CA5ACA5BALDH1A1KDM4ESMN1; SMN2 | |
| Trolamine SCHEMBL3283293 | 0.85 | CA5A (0.38) | CA5ACA5BALDH1A1KDM4ESMN1; SMN2 | |
| Nitric Acid SCHEMBL9007438 | 0.83 | ALDH1A1 (0.33) | CA5ACA5BALDH1A1KDM4ESMN1; SMN2 | |
| Nitric Acid SCHEMBL11756902 | 0.83 | POLB (0.34) | CA5ACA5BALDH1A1KDM4ESMN1; SMN2 | |
| Nitric Acid SCHEMBL11831019 | 0.83 | POLB (0.34) | CA5ACA5BALDH1A1KDM4ESMN1; SMN2 | |
| Nitric Acid SCHEMBL1832473 | 0.80 | ALDH1A1 (0.40) | CA5ACA5BALDH1A1KDM4ESMN1; SMN2 | |
| Trolamine SCHEMBL3884356 | 0.80 | MAPT (0.41) | ALDH1A1KDM4ESMN1; SMN2MAPTALOX15 | |
| Nitric Acid SCHEMBL8445719 | 0.79 | CA5A (0.42) | CA5ACA5BALDH1A1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5359919-A | Method of confinement of propellants for ignition | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1994-11-01 | — | — | US | disclosed |