Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL1399516 | 1.00 | TDP1 (0.47) | TDP1GLRA1SLC6A9OR51E2GABRR1 | |
| Methacrylic Acid SCHEMBL20917641 | 1.00 | TDP1 (0.47) | TDP1GLRA1SLC6A9OR51E2GABRR1 | |
| Methacrylic Acid SCHEMBL8678385 | 0.97 | TDP1 (0.45) | TDP1GLRA1SLC6A9OR51E2GABRR1 | |
| Methacrylic Acid SCHEMBL3284766 | 0.88 | TDP1 (0.43) | TDP1GLRA1SLC6A9OR51E2GABRR1 | |
| Methacrylic Acid SCHEMBL3117725 | 0.88 | ALDH1A1 (0.44) | TDP1GLRA1SLC6A9OR51E2GABRR1 | |
| Methacrylic Acid SCHEMBL1399502 | 0.88 | PAOX (0.44) | TDP1GLRA1SLC6A9OR51E2GABRR1 | |
| Methacrylic Acid SCHEMBL28271532 | 0.88 | TDP1 (0.43) | TDP1GLRA1SLC6A9OR51E2GABRR1 | |
| Methacrylic Acid SCHEMBL18222437 | 0.88 | — | — | |
| Methacrylic Acid SCHEMBL4931388 | 0.88 | — | — | |
| Methacrylic Acid SCHEMBL30238728 | 0.86 | PAOX (0.54) | TDP1GABRR1PAOXTSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117460782-A | Silicone hydrogel contact lenses | 茵洛有限公司 | 2024-01-26 | — | — | CN | claimed |
| CN-116327738-A | Patch containing cannabidiol | 宝泓生医股份有限公司 | 2023-06-27 | — | — | CN | claimed |
| WO-2021020512-A1 | DRUG-CONTAINING OPHTHALMIC LENS | 興和株式会社 | 2021-02-04 | — | — | WO | claimed |
| CN-119638918-A | Colored silicon polymer material and preparation method thereof | 江苏天眼医药科技股份有限公司 | 2025-03-18 | — | — | CN | disclosed |
| CN-119569962-A | Silicon polymer material and preparation method thereof | 烟台爱博诺德医用材料有限公司 | 2025-03-07 | — | — | CN | disclosed |
| CN-113655636-B | Contact lens for intraocular pressure monitoring | 明基材料有限公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-117460782-A | Silicone hydrogel contact lenses | 茵洛有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-116327738-A | Patch containing cannabidiol | 宝泓生医股份有限公司 | 2023-06-27 | — | — | CN | disclosed |
| WO-2021020512-A1 | DRUG-CONTAINING OPHTHALMIC LENS | 興和株式会社 | 2021-02-04 | — | — | WO | disclosed |
| US-5302633-A | Polymerizing a vinyl substituted polysaccharde on a porous support | NACALAI TESQUE, INC. (JP) | 1994-04-12 | — | — | US | disclosed |