Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 2/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | KLK1 | P06870 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301988 | 0.88 | TOP2A (0.40) | PTGER2F2PLGPLAUPLAT | |
| SCHEMBL9301220 | 0.84 | PTGER2 (0.43) | PTGER2F2PLGPLAUPLAT | |
| SCHEMBL9301722 | 0.81 | P2RY14 (0.63) | P2RY14ALOX5 | |
| SCHEMBL9300489 | 0.78 | PELI1 (0.46) | PTGER2PLGPLAUPLATKLK1 | |
| SCHEMBL7816757 | 0.75 | ALOX5 (0.49) | ALOX5PELI1HSD17B1HSD17B2 | |
| SCHEMBL3420178 | 0.72 | SLC6A2 (0.56) | P2RY14ALOX5 | |
| SCHEMBL27624039 | 0.71 | P2RY14 (0.52) | P2RY14PTGER2CNR2 | |
| SCHEMBL10026215 | 0.71 | PTPN1 (0.51) | P2RY14ALOX5 | |
| SCHEMBL9269222 | 0.70 | HSD17B1 (0.42) | PTGER2ALOX5PELI1CNR2GPR84 | |
| SCHEMBL8442653 | 0.70 | P2RY14 (0.58) | P2RY14PTGER2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1087907-A | Heteroaryl naphthalene as white (cell) triolefin biosynthesis inhibitor | MERCK FROSST CANADA INC (CA) | 1994-06-15 | — | — | CN | disclosed |
| US-5308852-A | Cardiovascular disorders | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0579304-A1 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1994-01-19 | — | — | EP | disclosed |
| WO-1994000444-A1 | HETEROARYLNAPHTHALENES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-01-06 | — | — | WO | disclosed |