Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 6/20 | 0.33 |
| ▸ | HTR2C | P28335 | 6/20 | 0.33 |
| ▸ | HTR2B | P41595 | 6/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300888 | 0.73 | HTR2A (0.39) | CHRNB2CHRNA4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL2766554 | 0.67 | HTR2A (0.50) | CHRNB2CHRNA4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL29723594 | 0.67 | HTR2A (0.50) | CHRNB2CHRNA4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL202263 | 0.67 | GRIN2D (0.35) | CHRNB2CHRNA4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL24832561 | 0.66 | ALDH1A1 (0.32) | CHRNB2CHRNA4GRIN2DGRIN3BGRIN1 | |
| Ammonia Solution, Strong SCHEMBL2786789 | 0.66 | HTR2A (0.49) | CHRNB2CHRNA4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL352937 | 0.66 | SIGMAR1 (0.47) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL7551766 | 0.66 | GRIN2D (0.34) | CHRNB2CHRNA4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL7545658 | 0.66 | GRIN2D (0.34) | CHRNB2CHRNA4GRIN2DGRIN3BGRIN1 | |
| Bromide SCHEMBL7360884 | 0.64 | HTR2A (0.47) | CHRNB2CHRNA4GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5362747-A | Promoters, inhibitors | ABBOTT LABORATORIES (US) | 1994-11-08 | — | — | US | disclosed |
| WO-1994012163-A1 | 2-NITROARYL AND 2-CYANOARYL COMPOUNDS AS REGULATORS OF NITRIC OXIDE SYNTHASE | ABBOTT LABORATORIES (US) | 1994-06-09 | — | — | WO | disclosed |