Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.67 |
| ▸ | GALR3 | O60755 | 3/20 | 0.66 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | PTAFR | P25105 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324796 | 0.83 | PTAFR (0.56) | PTAFR | |
| SCHEMBL3974904 | 0.81 | TNF (0.77) | TNFGALR3NR2F2RAB9APTAFR | |
| SCHEMBL8220572 | 0.81 | TNF (0.77) | TNFGALR3NR2F2RAB9APTAFR | |
| SCHEMBL6833621 | 0.81 | TNF (0.81) | TNFGALR3NR2F2RAB9AHDAC1 | |
| SCHEMBL231295 | 0.81 | TNF (1.00) | TNFGALR3NR2F2RAB9AHDAC1 | |
| SCHEMBL9302023 | 0.80 | PTAFR (0.66) | TNFGALR3NR2F2RAB9APTAFR | |
| Chlormidazole SCHEMBL30402878 | 0.80 | GALR3 (1.00) | TNFGALR3NR2F2RAB9ADRD2 | |
| Chlormidazole SCHEMBL148113 | 0.80 | GALR3 (1.00) | TNFGALR3NR2F2RAB9ADRD2 | |
| SCHEMBL9302639 | 0.79 | PTAFR (0.64) | TNFGALR3NR2F2RAB9APTAFR | |
| SCHEMBL3974900 | 0.79 | TNF (0.77) | TNFGALR3NR2F2RAB9APTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468971-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-02-05 | — | — | EP | claimed |
| WO-1990009997-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1990-09-07 | — | — | WO | claimed |
| US-5314880-A | Platelet activating factor antagonist | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1994-05-24 | — | — | US | disclosed |
| US-5276153-A | Antagonist of platelet activating factor for bronchodilation | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1994-01-04 | — | — | US | disclosed |
| EP-0468971-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |
| WO-1990009997-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1990-09-07 | — | — | WO | disclosed |