Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | CA1 | P00915 | 2/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA3 | P07451 | 1/20 | 0.57 |
| ▸ | TYR | P14679 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | CA6 | P23280 | 1/20 | 0.57 |
| ▸ | CA5A | P35218 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.57 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL8760212 | 1.00 | TSHR (0.71) | TSHRTP53CA1CA2SRD5A2 | |
| Terephthalic Acid SCHEMBL942934 | 1.00 | TSHR (0.71) | TSHRTP53CA1CA2SRD5A2 | |
| Paraben SCHEMBL28953307 | 0.90 | CA2 (0.76) | TSHRTP53CA1CA2SRD5A2 | |
| Benzoic Acid SCHEMBL3235670 | 0.89 | TSHR (0.74) | TSHRTP53CA1CA2SRD5A2 | |
| Benzoic Acid SCHEMBL3235664 | 0.89 | TSHR (0.74) | TSHRTP53CA1CA2SRD5A2 | |
| Benzoic Acid SCHEMBL11482567 | 0.89 | TSHR (0.74) | TSHRTP53CA1CA2SRD5A2 | |
| Benzoic Acid SCHEMBL30087353 | 0.89 | TSHR (0.74) | TSHRTP53CA1CA2SRD5A2 | |
| Aminobenzoic Acid SCHEMBL28605501 | 0.88 | TSHR (0.55) | TSHRTP53CA1CA2SRD5A2 | |
| Terephthalic Acid SCHEMBL28186926 | 0.88 | TSHR (0.55) | TSHRTP53CA1CA2SRD5A2 | |
| Maleic Acid SCHEMBL28020629 | 0.88 | BCL2L1 (0.68) | TSHRTP53CA1CA2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113881031-B | Polyether polyol and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-06-28 | — | — | CN | claimed |
| CN-111087597-B | Preparation method of high-activity polyether polyol | 中国石油化工股份有限公司 | 2023-01-24 | — | — | CN | claimed |
| US-4514487-A | POLYMERIZING A MONOMER IN THE PRESENCE OF A COLORANT AND AN ANTIOFFSET AGENT | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1985-04-30 | — | — | US | claimed |
| CN-113881031-B | Polyether polyol and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-112694620-B | Preparation method of hyperbranched polymer | 中国石油化工股份有限公司 | 2023-11-28 | — | — | CN | disclosed |
| CN-113801315-B | End-capped polyether containing phenylethane oxide and preparation method and application thereof | 中国石油化工股份有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-111087599-B | Process for preparing high molecular weight polyethylene oxides | 中国石油化工股份有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-111087600-B | Polyurethane elastomer resin and preparation method thereof | 中国石油化工股份有限公司 | 2023-03-03 | — | — | CN | disclosed |
| CN-111087597-B | Preparation method of high-activity polyether polyol | 中国石油化工股份有限公司 | 2023-01-24 | — | — | CN | disclosed |
| CN-112694607-B | Polyether polyol and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-113881031-A | Polyether polyol and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-01-04 | — | — | CN | disclosed |
| CN-113801333-A | Preparation method of amphiphilic hyperbranched polymer | 中国石油化工股份有限公司 | 2021-12-17 | — | — | CN | disclosed |
| CN-113801315-A | End-capped polyether containing phenylethane oxide, preparation method and application thereof | 中国石油化工股份有限公司 | 2021-12-17 | — | — | CN | disclosed |
| CN-112694607-A | Polyether polyol and preparation method and application thereof | 中国石油化工股份有限公司 | 2021-04-23 | — | — | CN | disclosed |
| CN-112694620-A | Method for producing hyperbranched polymers | 中国石油化工股份有限公司 | 2021-04-23 | — | — | CN | disclosed |
| CN-111087600-A | Polyurethane elastomer resin and preparation method thereof | 中国石油化工股份有限公司 | 2020-05-01 | — | — | CN | disclosed |
| CN-111087598-A | Preparation and use method of inorganic supported phosphazene catalyst | 中国石油化工股份有限公司 | 2020-05-01 | — | — | CN | disclosed |
| CN-111087597-A | Preparation method of high-activity polyether polyol | 中国石油化工股份有限公司 | 2020-05-01 | — | — | CN | disclosed |
| CN-111087599-A | Process for preparing high molecular weight polyethylene oxides | 中国石油化工股份有限公司 | 2020-05-01 | — | — | CN | disclosed |
| US-5344674-A | Protective coatings for metal surfaces | PHILLIPS PETROLEUM COMPANY (US) | 1994-09-06 | — | — | US | disclosed |