Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | CA1 | P00915 | 2/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA3 | P07451 | 1/20 | 0.57 |
| ▸ | TYR | P14679 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | CA6 | P23280 | 1/20 | 0.57 |
| ▸ | CA5A | P35218 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.57 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL9300604 | 1.00 | TSHR (0.71) | TSHRTP53CA1CA2SRD5A2 | |
| Terephthalic Acid SCHEMBL8760212 | 1.00 | TSHR (0.71) | TSHRTP53CA1CA2SRD5A2 | |
| Paraben SCHEMBL28953307 | 0.90 | CA2 (0.76) | TSHRTP53CA1CA2SRD5A2 | |
| Benzoic Acid SCHEMBL3235670 | 0.89 | TSHR (0.74) | TSHRTP53CA1CA2SRD5A2 | |
| Benzoic Acid SCHEMBL3235664 | 0.89 | TSHR (0.74) | TSHRTP53CA1CA2SRD5A2 | |
| Benzoic Acid SCHEMBL11482567 | 0.89 | TSHR (0.74) | TSHRTP53CA1CA2SRD5A2 | |
| Benzoic Acid SCHEMBL30087353 | 0.89 | TSHR (0.74) | TSHRTP53CA1CA2SRD5A2 | |
| Aminobenzoic Acid SCHEMBL28605501 | 0.88 | TSHR (0.55) | TSHRTP53CA1CA2SRD5A2 | |
| Terephthalic Acid SCHEMBL28186926 | 0.88 | TSHR (0.55) | TSHRTP53CA1CA2SRD5A2 | |
| Maleic Acid SCHEMBL28020629 | 0.88 | BCL2L1 (0.68) | TSHRTP53CA1CA2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7867680-B2 | Non-magnetic toner for one-component development and method of preparing the toner, and image developer, image forming apparatus, process cartridge and image forming method | RICOH COMPANY LIMITED (JP) | 2011-01-11 | — | — | US | disclosed |
| EP-0414416-B1 | Aromatic polyanhydride compositions | MASSACHUSETTS INST TECHNOLOGY (US) | 1997-06-04 | — | — | EP | disclosed |
| WO-1992010206-A1 | USE OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE 2 IN THE TREATMENT OF CANCER | DELTA BIOTECHNOLOGY LIMITED (GB) | 1992-06-25 | — | — | WO | disclosed |
| US-4997904-A | Drug delivery | NOVA PHARMACEUTICAL CORPORATION (US) | 1991-03-05 | — | — | US | disclosed |
| EP-0414416-A2 | Aromatic polyanhydride compositions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1991-02-27 | — | — | EP | disclosed |
| US-4309297-A | Heat storage material | NIPPON PETROCHEMICALS COMPANY, LTD. (JP) | 1982-01-05 | — | — | US | disclosed |