Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.68 |
| ▸ | BAD | Q92934 | 1/20 | 0.68 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27498 | 0.88 | BCL2L1 (0.85) | BCL2L1BADMITFTP53TSHR | |
| SCHEMBL4570568 | 0.88 | BCL2L1 (0.85) | BCL2L1BADMITFTP53TSHR | |
| Terephthalic Acid SCHEMBL8760212 | 0.88 | TSHR (0.71) | TP53TSHRCES2CES1CA1 | |
| SCHEMBL18670950 | 0.88 | BCL2L1 (0.85) | BCL2L1BADMITFTP53TSHR | |
| Terephthalic Acid SCHEMBL942934 | 0.88 | TSHR (0.71) | TP53TSHRCES2CES1CA1 | |
| Terephthalic Acid SCHEMBL9300604 | 0.88 | TSHR (0.71) | TP53TSHRCES2CES1CA1 | |
| SCHEMBL17332135 | 0.85 | BCL2L1 (0.81) | BCL2L1BADMITFTP53TSHR | |
| Fluoride SCHEMBL10732554 | 0.85 | BCL2L1 (0.81) | BCL2L1BADMITFTP53TSHR | |
| SCHEMBL11452380 | 0.85 | BCL2L1 (0.81) | BCL2L1BADMITFTP53TSHR | |
| SCHEMBL22734857 | 0.85 | BCL2L1 (0.81) | BCL2L1BADMITFTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105745191-A | Method for preparing silodosin and intermediate thereof | 上海科胜药物研发有限公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-104693090-A | Silodosin and preparation methods for intermediates thereof | SHANGHAI SYNCORES TECHNOLOGIES INC | 2015-06-10 | — | — | CN | disclosed |