Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 2/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24224717 | 0.81 | HTR1A (0.38) | HTR1ASLC6A2SLC6A4FPR2PROKR1 | |
| SCHEMBL15905112 | 0.81 | KMT2A (0.46) | HTR1ASLC6A2MAPK1HTTKMT2A | |
| SCHEMBL15905410 | 0.79 | KMT2A (0.44) | MAPK1HTTKMT2AMAPTNPSR1 | |
| SCHEMBL2834920 | 0.76 | KMT2A (0.40) | MAPK1HTTKMT2AMAPTNPSR1 | |
| SCHEMBL930657 | 0.76 | KDM4E (0.40) | MAPK1HTTKMT2AMAPTNPSR1 | |
| SCHEMBL30555341 | 0.74 | MAPK14 (0.36) | SLC6A4MAPK1HTTKMT2AMAPT | |
| SCHEMBL720899 | 0.72 | RXRA (0.38) | MAPK1HTTKMT2AMAPTNPSR1 | |
| SCHEMBL20425165 | 0.72 | SLC6A2 (0.47) | HTR1ASLC6A2SLC6A4 | |
| SCHEMBL719524 | 0.71 | KDM1A (0.44) | SLC6A2SLC6A4HTR2AHTR2CKDM1A | |
| SCHEMBL931713 | 0.70 | MAPT (0.31) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002409-A1 | 5H-PYRROLO[3,4-£>]PYRAZIN-7-AMINE DERIVATIVES INHIBITORS OF BETA-SECRETASE | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |