Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL930657 | 0.76 | KDM4E (0.40) | MAPT | |
| SCHEMBL31327405 | 0.75 | ERN1 (0.38) | — | |
| SCHEMBL12579445 | 0.74 | NFE2L2 (0.32) | — | |
| SCHEMBL930098 | 0.70 | HTR1A (0.36) | MAPT | |
| SCHEMBL23386893 | 0.69 | ERN1 (0.31) | — | |
| SCHEMBL3390811 | 0.69 | TDP1 (0.36) | MAPT | |
| SCHEMBL3394195 | 0.69 | RAPGEF4 (0.35) | MAPT | |
| SCHEMBL19453313 | 0.68 | FFAR4 (0.32) | — | |
| Ammonia Solution, Strong SCHEMBL27837347 | 0.67 | RAPGEF4 (0.33) | — | |
| SCHEMBL10986 | 0.66 | CA2 (0.41) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002409-A1 | 5H-PYRROLO[3,4-£>]PYRAZIN-7-AMINE DERIVATIVES INHIBITORS OF BETA-SECRETASE | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002409-A1 | 5H-PYRROLO[3,4-£>]PYRAZIN-7-AMINE DERIVATIVES INHIBITORS OF BETA-SECRETASE | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |