Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.51 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301889 | 0.80 | ESR2 (0.41) | ALOX5TDP1 | |
| SCHEMBL9303261 | 0.78 | P2RY14 (0.57) | ALOX5P2RY14CASP3SENP8SENP7 | |
| SCHEMBL9302951 | 0.77 | P2RY14 (0.56) | ALOX5P2RY14CASP3SENP8SENP7 | |
| SCHEMBL9305354 | 0.76 | P2RY14 (0.60) | ALOX5P2RY14MAOBMEN1KMT2A | |
| SCHEMBL9301069 | 0.76 | ALOX5 (0.45) | ALOX5P2RY14CASP3SENP8SENP7 | |
| SCHEMBL9303016 | 0.74 | P2RY14 (0.61) | ALOX5P2RY14CASP3SENP8SENP7 | |
| SCHEMBL9303687 | 0.74 | P2RY14 (0.57) | ALOX5P2RY14MAOBMEN1KMT2A | |
| SCHEMBL9301951 | 0.72 | P2RY14 (0.55) | ALOX5P2RY14MAOBMAOAACHE | |
| SCHEMBL9303702 | 0.70 | P2RY14 (0.53) | ALOX5P2RY14MAOBNPC1RAB9A | |
| SCHEMBL9301998 | 0.70 | P2RY14 (0.61) | ALOX5P2RY14MAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5308852-A | Cardiovascular disorders | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0579304-A1 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1994-01-19 | — | — | EP | disclosed |
| WO-1994000444-A1 | HETEROARYLNAPHTHALENES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-01-06 | — | — | WO | disclosed |