Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.43 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | KCNN3 | Q9UGI6 | 3/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.33 |
| ▸ | CDK9 | P50750 | 4/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | S100A4 | P26447 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3460690 | 0.80 | PIK3CG (0.48) | PDE10AUBE2MDCUN1D1PDE2APIK3CG | |
| SCHEMBL22932762 | 0.78 | MEN1 (0.43) | PDE10AUBE2MDCUN1D1PDE2AKCNN3 | |
| SCHEMBL4431791 | 0.77 | ALDH1A1 (0.50) | PDE10AUBE2MDCUN1D1PDE2APIK3CG | |
| SCHEMBL659433 | 0.77 | PDE10A (0.67) | PDE10AUBE2MDCUN1D1PDE2AKCNN3 | |
| SCHEMBL4102510 | 0.77 | PDE10A (0.43) | PDE10AUBE2MDCUN1D1PDE2AKCNN3 | |
| SCHEMBL20406305 | 0.77 | PDE10A (0.43) | PDE10AUBE2MDCUN1D1PDE2AKCNN3 | |
| SCHEMBL10408224 | 0.77 | PDE10A (0.43) | PDE10AUBE2MDCUN1D1PDE2AKCNN3 | |
| SCHEMBL7438434 | 0.77 | PRKAB2 (0.48) | PDE10AKCNN3CCNT1CDK9CRHR1 | |
| SCHEMBL13769278 | 0.74 | PDE2A (0.46) | PDE10APDE2AKCNN3CCNT1CDK9 | |
| SCHEMBL21212282 | 0.74 | PDE2A (0.41) | PDE10AUBE2MDCUN1D1PDE2AKCNN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |
| EP-3078662-A1 | PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS | Array Biopharma, Inc. (US) | 2016-10-12 | — | — | EP | disclosed |
| EP-2727910-B1 | Pyridin-2-yl-thiourea and Pyridin-2-yl-amine derivatives as intermediates for the preparation of Pyridin-2yl-amino-1,2,4-thiadiazole glucokinase activators | ARRAY BIOPHARMA INC (US) | 2016-03-16 | — | — | EP | disclosed |
| EP-2727910-A1 | Pyridin-2-yl-thiourea and Pyridin-2-yl-amine derivatives as intermediates for the preparation of Pyridin-2yl-amino-1,2,4-thiadiazole glucokinase activators | Array Biopharma, Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| US-5319140-A | Antibiotics | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | disclosed |
| US-5138066-A | Intermediates for cephalosporins with sulfur-containing oxyimino side chain | HOFFMANN-LA ROCHE, INC. (US) | 1992-08-11 | — | — | US | disclosed |
| US-5073550-A | Bactericides | HOFFMANN-LA ROCHE INC. (US) | 1991-12-17 | — | — | US | disclosed |
| US-5036064-A | Antibiotics | HOFFMANN-LA ROCHE INC. (US) | 1991-07-30 | — | — | US | disclosed |
| US-4966900-A | FOR MICROBISM THERAPY, BACTERIAL INFECTIONS | SANKEI PHARMACEUTICAL COMPANY LTD. (JP) | 1990-10-30 | — | — | US | disclosed |
| EP-0303172-A2 | Oxyimino-cephalosporins | F. HOFFMANN-LA ROCHE AG (CH) | 1989-02-15 | — | — | EP | disclosed |
| EP-0254495-A2 | Beta-Lactam compound, method for preparing the same, medicinal composition for bacterially infectious disease therapy containing the same and intermediates for synthesis of the same | SANKEI PHARMACEUTICAL COMPANY LIMITED (JP) | 1988-01-27 | — | — | EP | disclosed |