Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301223 | 1.00 | MAPT (0.49) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29796135 | 0.79 | ALDH1A1 (0.48) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23213140 | 0.79 | ALDH1A1 (0.48) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9301219 | 0.76 | MAPT (0.46) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27852984 | 0.74 | MAPT (0.59) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9545603 | 0.74 | ALDH1A1 (0.52) | MAPTALDH1A1POLBHTTL3MBTL1 | |
| SCHEMBL6686706 | 0.72 | MAPT (0.48) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6686710 | 0.72 | MAPT (0.48) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6686703 | 0.72 | MAPT (0.48) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14261779 | 0.72 | ITGB2 (0.49) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360802-A | Antagonists of cholecystokinin and gastrin | MERCK SHARPE & DOHME LTD. | 1994-11-01 | — | — | US | disclosed |
| EP-0514133-A1 | Benzodiazepine derivatives, compositions containing them and their use in therapy | MERCK SHARP & DOHME LTD. (GB) | 1992-11-19 | — | — | EP | disclosed |