Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23213140 | 0.78 | ALDH1A1 (0.48) | MAPTALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL29796135 | 0.78 | ALDH1A1 (0.48) | MAPTALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL7101531 | 0.77 | MAPT (0.46) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL9301216 | 0.76 | MAPT (0.49) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL9301223 | 0.76 | MAPT (0.49) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL9545603 | 0.73 | ALDH1A1 (0.52) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL30822838 | 0.71 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL4746148 | 0.71 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL27449893 | 0.70 | CES2 (0.59) | MAPTALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL4717161 | 0.70 | HSP90AA1 (0.46) | MAPTALDH1A1SMN1; SMN2LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360802-A | Antagonists of cholecystokinin and gastrin | MERCK SHARPE & DOHME LTD. | 1994-11-01 | — | — | US | disclosed |
| EP-0514133-A1 | Benzodiazepine derivatives, compositions containing them and their use in therapy | MERCK SHARP & DOHME LTD. (GB) | 1992-11-19 | — | — | EP | disclosed |