Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL929841 | 0.88 | MAPT (0.51) | SYKNPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL930913 | 0.83 | MAP2K1 (0.55) | SYKMAPTTHRBTDP1 | |
| SCHEMBL928951 | 0.77 | SMN1; SMN2 (0.47) | NPSR1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL20560379 | 0.74 | CASP1 (0.54) | SMN1; SMN2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1353552 | 0.74 | SYK (1.00) | SYKNPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL929220 | 0.72 | MAP2K1 (0.43) | — | |
| SCHEMBL8656659 | 0.72 | GLP1R (0.46) | NPSR1KMT2AXBP1KDM4EALDH1A1 | |
| SCHEMBL12943698 | 0.72 | MEN1 (0.38) | SYKMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL4713013 | 0.71 | SYK (0.67) | SYKNPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL609694 | 0.70 | CASP1 (0.43) | SMN1; SMN2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110015392-A1 | PROCESS FOR PREPARING PYRIDONE DERIVATIVES 226 | ASTRAZENECA AB | 2011-01-20 | — | — | US | disclosed |
| US-20110015392-A1 | PROCESS FOR PREPARING PYRIDONE DERIVATIVES 226 | ASTRAZENECA AB | 2011-01-20 | — | — | US | disclosed |
| EP-2252588-A2 | PROCESS FOR PREPARING PYRIDONE DERIVATIVES | AstraZeneca AB (SE) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009101432-A2 | PROCESS FOR PREPARING PYRIDONE DERIVATIVES 226 | ASTRAZENECA AB (SE) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009101432-A2 | PROCESS FOR PREPARING PYRIDONE DERIVATIVES 226 | ASTRAZENECA AB (SE) | 2009-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015392-A1 | PROCESS FOR PREPARING PYRIDONE DERIVATIVES 226 | PDXK, MAPK1, PNPO | SYK 668/4885NPSR1 3102/4885MEN1 529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.