Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | CDC25C | P30307 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL930913 | 0.86 | MAP2K1 (0.55) | TDP1MAPT | |
| SCHEMBL929841 | 0.83 | MAPT (0.51) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL930160 | 0.77 | SYK (0.59) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL929220 | 0.75 | MAP2K1 (0.43) | — | |
| SCHEMBL28420937 | 0.74 | POLB (0.49) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL20560379 | 0.73 | CASP1 (0.54) | SMN1; SMN2KDM4EALDH1A1MAPTTSHR | |
| SCHEMBL1202883 | 0.73 | CDC25B (0.52) | SMN1; SMN2KDM4EALDH1A1TDP1MAPT | |
| SCHEMBL10550202 | 0.72 | THRB (0.53) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL3790215 | 0.71 | PIM1 (0.50) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL28990216 | 0.71 | ALDH1A1 (0.46) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110015392-A1 | PROCESS FOR PREPARING PYRIDONE DERIVATIVES 226 | ASTRAZENECA AB | 2011-01-20 | — | — | US | disclosed |
| US-20110015392-A1 | PROCESS FOR PREPARING PYRIDONE DERIVATIVES 226 | ASTRAZENECA AB | 2011-01-20 | — | — | US | disclosed |
| EP-2252588-A2 | PROCESS FOR PREPARING PYRIDONE DERIVATIVES | AstraZeneca AB (SE) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009101432-A2 | PROCESS FOR PREPARING PYRIDONE DERIVATIVES 226 | ASTRAZENECA AB (SE) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009101432-A2 | PROCESS FOR PREPARING PYRIDONE DERIVATIVES 226 | ASTRAZENECA AB (SE) | 2009-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015392-A1 | PROCESS FOR PREPARING PYRIDONE DERIVATIVES 226 | PDXK, MAPK1, PNPO | SMN1; SMN2 2152/4885NPC1 4522/4885RAB9A 339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.