Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | HNF4A | P41235 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | RARA | P10276 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6671557 | 0.88 | RXRA (0.36) | RXRAHNF4ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL9304041 | 0.87 | RARA (0.41) | RXRAHNF4ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL6669533 | 0.87 | RXRA (0.36) | RXRAHNF4ANPSR1TBXAS1CYP3A4 | |
| SCHEMBL9302053 | 0.84 | CYP3A4 (0.43) | TBXAS1CYP3A4RARARARBRARG | |
| SCHEMBL9301689 | 0.84 | RXRA (0.35) | RXRAHNF4ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL6666407 | 0.84 | RARA (0.40) | RXRAHNF4ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL6671507 | 0.83 | RXRA (0.37) | RXRAHNF4ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL9302755 | 0.83 | RXRA (0.37) | RXRAHNF4ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL9302057 | 0.82 | NPC1 (0.33) | NPC1MAPTSMN1; SMN2RXFP1RAB9A | |
| SCHEMBL9301656 | 0.82 | RXRA (0.36) | RXRAHNF4ANPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354752-A | A dimethylthiochroman or dimethylchroman-6-yl-ethynyl-pyridazin- or pyrimidin- or pyrazin-for treating skin disorders psoriasis | ALLERGAN, INC. (US) | 1994-10-11 | — | — | US | claimed |