Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 18/20 | 0.56 |
| ▸ | ESRRB | O95718 | 1/20 | 0.50 |
| ▸ | ESRRA | P11474 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38656885 | 0.88 | ALOX5 (0.72) | ALOX5 | |
| SCHEMBL9302851 | 0.88 | ALOX5 (0.72) | ALOX5 | |
| SCHEMBL9125611 | 0.88 | ALOX5 (0.56) | ALOX5TOP2A | |
| SCHEMBL7659535 | 0.82 | ALOX5 (0.62) | ALOX5ESRRBESRRATOP2A | |
| SCHEMBL38657443 | 0.73 | ALOX5 (0.69) | ALOX5 | |
| SCHEMBL16272594 | 0.73 | ALOX5 (1.00) | ALOX5TOP2A | |
| SCHEMBL7656932 | 0.70 | ALOX5 (0.54) | ALOX5TOP2A | |
| SCHEMBL8081262 | 0.69 | ALOX5 (0.62) | ALOX5TOP2A | |
| SCHEMBL9277584 | 0.68 | HSD17B3 (0.43) | ALOX5 | |
| SCHEMBL29582148 | 0.68 | ALOX5 (1.00) | ALOX5TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |