Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.68 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 4/20 | 0.52 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1270411 | 0.75 | ALOX5 (0.56) | ALOX5MAOB | |
| SCHEMBL30817881 | 0.75 | ALOX5 (0.56) | ALOX5MAOB | |
| SCHEMBL316203 | 0.74 | MAOB (0.69) | ALOX5MAOBGSTP1MAOA | |
| SCHEMBL9301998 | 0.74 | P2RY14 (0.61) | ALOX5P2RY14MAOB | |
| SCHEMBL9305354 | 0.73 | P2RY14 (0.60) | ALOX5P2RY14MAOB | |
| SCHEMBL9724184 | 0.73 | ELANE (0.42) | ALOX5MAOBGSTP1MAOA | |
| SCHEMBL9301951 | 0.72 | P2RY14 (0.55) | ALOX5P2RY14MAOBGSTP1MAOA | |
| SCHEMBL9303016 | 0.71 | P2RY14 (0.61) | ALOX5P2RY14MAOB | |
| SCHEMBL10623137 | 0.71 | ALDH1A1 (0.71) | MAOBMAOA | |
| SCHEMBL9303687 | 0.71 | P2RY14 (0.57) | ALOX5P2RY14MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |