Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 10/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 10/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 5/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSPO | P30536 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.31 |
| ▸ | LPAR4 | Q99677 | 2/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | SGPL1 | O95470 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301175 | 0.91 | FDPS (0.33) | LPAR3 | |
| SCHEMBL9300482 | 0.88 | FDPS (0.40) | LPAR3LPAR1LPAR2S1PR4S1PR1 | |
| SCHEMBL9303056 | 0.86 | FDPS (0.34) | — | |
| SCHEMBL9301453 | 0.83 | FDPS (0.36) | — | |
| SCHEMBL9301474 | 0.79 | FDPS (0.43) | — | |
| SCHEMBL9301258 | 0.77 | FDPS (0.38) | ALDH1A1 | |
| SCHEMBL5075884 | 0.77 | FDPS (0.45) | — | |
| SCHEMBL6670360 | 0.77 | FDPS (0.45) | — | |
| SCHEMBL9301070 | 0.76 | FDPS (0.37) | — | |
| SCHEMBL6668133 | 0.71 | CYP3A4 (0.42) | LPAR3LPAR1LPAR2LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5350743-A | Treatment of osteoporosis | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1994-09-27 | — | — | US | disclosed |
| EP-0498424-A1 | Bisphosphonic acid derivatives and bone resorption inhibitors containing them | Kaken Pharmaceutical Co., Ltd. (JP) | 1992-08-12 | — | — | EP | disclosed |