Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 3/20 | 0.59 |
| ▸ | GRM5 | P41594 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.35 |
| ▸ | USP2 | O75604 | 7/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.35 |
| ▸ | TSHR | P16473 | 6/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300273 | 0.96 | FDPS (0.64) | FDPSGRM5CYP3A4CYP2D6USP2 | |
| SCHEMBL9301193 | 0.93 | FDPS (0.53) | FDPSGRM5CYP3A4CYP2D6USP2 | |
| SCHEMBL9300041 | 0.86 | FDPS (0.54) | FDPSGRM5CYP2C19TSHR | |
| SCHEMBL9300487 | 0.81 | FDPS (0.63) | FDPSCYP2C19TSHRANPEPERAP2 | |
| SCHEMBL9301139 | 0.79 | FDPS (0.43) | FDPSCYP3A4CYP2D6USP2CYP2C9 | |
| SCHEMBL9301543 | 0.79 | FDPS (0.59) | FDPSCYP2C19TSHR | |
| SCHEMBL9300465 | 0.78 | FDPS (0.53) | FDPSCYP3A4CYP2D6USP2CYP2C9 | |
| SCHEMBL2472093 | 0.75 | FDPS (1.00) | FDPSTSHRMEN1ALDH1A1KMT2A | |
| N-(Hexamethyleneimino)Methylenebisphosphonic Acid SCHEMBL12309768 | 0.75 | FDPS (1.00) | FDPSTSHRMEN1ALDH1A1KMT2A | |
| SCHEMBL9301972 | 0.73 | FDPS (0.39) | FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5350743-A | Treatment of osteoporosis | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1994-09-27 | — | — | US | disclosed |
| EP-0498424-A1 | Bisphosphonic acid derivatives and bone resorption inhibitors containing them | Kaken Pharmaceutical Co., Ltd. (JP) | 1992-08-12 | — | — | EP | disclosed |