SCHEMBL9302251

SCHEMBL9302251

CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccc(O)cc12

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 15/20 0.77
MTNR1B P49286 15/20 0.77
HPGD P15428 5/20 0.77
CYP1A2 P05177 4/20 0.77
CYP3A4 P08684 4/20 0.77
CYP2C19 P33261 3/20 0.77
TSHR P16473 2/20 0.77
TDP1 Q9NUW8 2/20 0.77
CYP2C9 P11712 2/20 0.77
MEN1 O00255 1/20 0.77
KMT2A Q03164 1/20 0.77
ALDH1A1 P00352 4/20 0.56
CYP2D6 P10635 3/20 0.56
MAPT P10636 2/20 0.56
ALOX15 P16050 1/20 0.56
KDM4E B2RXH2 3/20 0.51
SPR P35270 2/20 0.51
IDO1 P14902 1/20 0.51
BLM P54132 1/20 0.51
NOTUM Q6P988 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9304093 0.88 MTNR1A (0.75) MTNR1AMTNR1BHPGDCYP1A2CYP3A4
Luzindole SCHEMBL4869000 0.87 MTNR1A (1.00) MTNR1AMTNR1BHPGDCYP1A2CYP3A4
SCHEMBL9304037 0.86 MTNR1A (1.00) MTNR1AMTNR1BHPGDCYP1A2CYP3A4
SCHEMBL31543670 0.83 CYP1A2 (0.58) MTNR1AMTNR1BHPGDCYP1A2CYP3A4
SCHEMBL26989629 0.82 CYP1A2 (0.54) MTNR1AMTNR1BHPGDCYP1A2CYP3A4
SCHEMBL5348486 0.82 MTNR1A (0.64) MTNR1AMTNR1BHPGDCYP1A2CYP3A4
SCHEMBL31543662 0.81 MTNR1A (0.55) MTNR1AMTNR1BHPGDCYP1A2CYP3A4
SCHEMBL31543650 0.80 KDM4E (0.60) MTNR1AMTNR1BHPGDCYP1A2CYP3A4
SCHEMBL31543625 0.79 SPR (0.72) MTNR1AMTNR1BHPGDCYP1A2CYP3A4
SCHEMBL31543676 0.79 SPR (0.72) MTNR1AMTNR1BHPGDCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5283343-A Melatonin antagonists WHITBY RESEARCH, INC. (US) 1994-02-01 US disclosed
US-5093352-A Melatonin inhibitor, sleep, 2-aryl N-acetyl tryptamine WHITBY RESEARCH, INC. (US) 1992-03-03 US disclosed