Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 8/20 | 0.46 |
| ▸ | FDPS | P14324 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300979 | 0.84 | OPRM1 (0.49) | KCNH2HRH3L3MBTL1OPRM1SLC18A3 | |
| SCHEMBL9301335 | 0.76 | KCNH2 (0.52) | KCNH2HRH3OPRM1SIGMAR1GRIN2B | |
| SCHEMBL2661616 | 0.74 | KCNH2 (0.56) | KCNH2HRH3OPRM1SLC18A3CYP2D6 | |
| SCHEMBL27498941 | 0.73 | KCNH2 (0.60) | KCNH2HRH3L3MBTL1OPRM1SLC18A3 | |
| SCHEMBL6221180 | 0.73 | SLC18A3 (0.48) | KCNH2HRH3OPRM1SLC18A3SIGMAR1 | |
| SCHEMBL2603282 | 0.73 | HRH3 (0.69) | KCNH2HRH3OPRM1SLC18A3CYP2D6 | |
| SCHEMBL7060188 | 0.72 | SLC18A3 (0.50) | KCNH2HRH3L3MBTL1SLC18A3CYP2D6 | |
| Phosphoric Acid SCHEMBL27640844 | 0.72 | SLC18A3 (0.49) | SLC18A3CYP2D6SIGMAR1TSHRSMN1; SMN2 | |
| SCHEMBL6190526 | 0.72 | KCNH2 (0.51) | KCNH2HRH3L3MBTL1OPRM1SLC18A3 | |
| SCHEMBL753850 | 0.72 | LMNA (0.63) | KCNH2HRH3L3MBTL1OPRM1SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5350743-A | Treatment of osteoporosis | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1994-09-27 | — | — | US | disclosed |
| EP-0498424-A1 | Bisphosphonic acid derivatives and bone resorption inhibitors containing them | Kaken Pharmaceutical Co., Ltd. (JP) | 1992-08-12 | — | — | EP | disclosed |