Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301506 | 0.82 | MAPT (0.38) | MAPTSIRT6ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8111771 | 0.80 | MAPT (0.47) | MAPTSIRT6ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9564447 | 0.79 | MAPT (0.52) | MAPTSIRT6ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL14922295 | 0.78 | ALDH1A1 (0.50) | MAPTALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL8116485 | 0.77 | MAPT (0.41) | MAPTSIRT6ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL10770620 | 0.74 | MAPT (0.47) | MAPTSIRT6ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL16532774 | 0.72 | SIRT6 (0.54) | MAPTSIRT6ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL22471423 | 0.72 | MAPT (0.59) | MAPTSIRT6ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8097435 | 0.72 | MAPT (0.56) | MAPTSIRT6ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8112311 | 0.71 | MAPT (0.39) | MAPTSIRT6ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283248-A | Bactericides, enzyme inhibitor of DNA-gyrase in bacteria | HOFFMANN-LA ROCHE INC. (US) | 1994-02-01 | — | — | US | disclosed |