Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | LIPE | Q05469 | 1/20 | 0.53 |
| ▸ | SGMS2 | Q8NHU3 | 11/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | ALPG | P10696 | 1/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11603988 | 0.90 | MAPT (0.55) | MAPTMAPK1TDP1L3MBTL1LIPE | |
| SCHEMBL22416666 | 0.86 | MAPT (0.51) | MAPTMAPK1TDP1L3MBTL1LIPE | |
| SCHEMBL22416706 | 0.86 | MAPT (0.51) | MAPTMAPK1TDP1L3MBTL1LIPE | |
| SCHEMBL3458384 | 0.85 | TDP1 (0.55) | MAPTMAPK1TDP1L3MBTL1LIPE | |
| SCHEMBL28888783 | 0.85 | LIPE (0.54) | MAPTMAPK1TDP1L3MBTL1LIPE | |
| SCHEMBL27810149 | 0.85 | LIPE (0.54) | MAPTMAPK1TDP1L3MBTL1LIPE | |
| SCHEMBL477534 | 0.84 | DRD2 (0.55) | MAPTMAPK1TDP1L3MBTL1LIPE | |
| SCHEMBL16797593 | 0.84 | SGMS2 (0.49) | MAPTMAPK1TDP1L3MBTL1LIPE | |
| SCHEMBL11601212 | 0.84 | SGMS2 (0.49) | MAPTMAPK1TDP1L3MBTL1LIPE | |
| SCHEMBL16797699 | 0.84 | SGMS2 (0.49) | MAPTMAPK1TDP1L3MBTL1LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310750-A | Heterocyclic compounds useful as α2 -adrenoceptor antagonists | BEECHAM GROUP P.L.C. (GB) | 1994-05-10 | — | — | US | disclosed |
| EP-0313288-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ALPHA 2-ADRENO-RECEPTOR ANTAGONISTS | BEECHAM GROUP PLC (GB) | 1992-12-30 | — | — | EP | disclosed |
| US-5021445-A | Hyperglycemic and hypertensive agents; anticoagulants, alpha2-adrenoceptor antagonists | BEECHAM GROUP P.L.C. (GB) | 1991-06-04 | — | — | US | disclosed |
| EP-0313288-A1 | Imidazole derivatives, process for their preparation and their use as alpha 2-adreno-receptor antagonists | BEECHAM GROUP PLC (GB) | 1989-04-26 | — | — | EP | disclosed |