Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 6/20 | 0.36 |
| ▸ | RARB | P10826 | 6/20 | 0.36 |
| ▸ | RARG | P13631 | 6/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | HNF4A | P41235 | 1/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.32 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301685 | 0.89 | RXRA (0.36) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL9304033 | 0.85 | RARA (0.39) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL9302100 | 0.84 | RARA (0.53) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL9817759 | 0.83 | CYP26A1 (0.40) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL9302931 | 0.83 | RARA (0.39) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL9817669 | 0.83 | CYP4F2 (0.43) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL6669569 | 0.83 | RARA (0.43) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL6667261 | 0.82 | RARA (0.44) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL9817779 | 0.81 | RARA (0.37) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL9817748 | 0.81 | CYP26A1 (0.41) | RARARARBRARGCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354752-A | A dimethylthiochroman or dimethylchroman-6-yl-ethynyl-pyridazin- or pyrimidin- or pyrazin-for treating skin disorders psoriasis | ALLERGAN, INC. (US) | 1994-10-11 | — | — | US | claimed |