Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1193890 | 0.85 | ALOX5 (0.60) | ALOX5 | |
| SCHEMBL8747780 | 0.76 | ALOX5 (0.34) | ALOX5 | |
| SCHEMBL27908645 | 0.76 | SLC6A4 (0.53) | ALOX5KDM4EHTTHSD17B10 | |
| SCHEMBL20819582 | 0.74 | ALOX5 (0.57) | ALOX5 | |
| SCHEMBL1040389 | 0.74 | OPRM1 (0.54) | ALOX5KDM4EHTTHSD17B10 | |
| SCHEMBL16024156 | 0.74 | OPRM1 (0.54) | ALOX5KDM4EHTTHSD17B10 | |
| SCHEMBL1040539 | 0.74 | OPRM1 (0.54) | ALOX5KDM4EHTTHSD17B10 | |
| SCHEMBL25840164 | 0.73 | ALOX5 (0.44) | ALOX5 | |
| SCHEMBL28032631 | 0.73 | SLC6A4 (0.50) | ALOX5 | |
| SCHEMBL3692139 | 0.73 | ALOX5 (0.48) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |