Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8747881 | 0.78 | HDAC4 (0.40) | OPRM1OPRL1PNMTHSD11B1 | |
| SCHEMBL9302960 | 0.76 | ALOX5 (0.52) | ALOX5 | |
| SCHEMBL9247121 | 0.75 | SLC16A3 (0.46) | — | |
| SCHEMBL27693324 | 0.74 | OPRD1 (0.41) | ALOX5CYP4F2CYP4A11TRPA1ALDH1A1 | |
| SCHEMBL1193890 | 0.74 | ALOX5 (0.60) | ALOX5 | |
| SCHEMBL22070497 | 0.71 | CYP4F2 (0.43) | CYP4F2CYP4A11OPRM1HSD11B1 | |
| SCHEMBL12185113 | 0.70 | OPRL1 (0.42) | ALOX5CYP4F2CYP4A11TRPA1ALDH1A1 | |
| Methoxymethane SCHEMBL28161427 | 0.70 | TSHR (0.50) | CYP4F2CYP4A11TRPA1ALDH1A1TSHR | |
| SCHEMBL8747855 | 0.68 | — | — | |
| SCHEMBL8747861 | 0.68 | IDO1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0599732-B1 | Derivatives of 1-phenylbicyclo-2,2,2-octane, their preparation process and pharmaceutical compositions containing them | ADIR (FR) | 1997-03-12 | — | — | EP | disclosed |
| US-5403953-A | Antiarthritic and -inflammatory agents | ADIR ET COMPAGNIE (FR) | 1995-04-04 | — | — | US | disclosed |
| EP-0599732-A1 | Derivatives of 1-phenylbicyclo-2,2,2-octane, their preparation process and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-06-01 | — | — | EP | disclosed |