Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.43 |
| ▸ | PPARA | Q07869 | 9/20 | 0.41 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | FDFT1 | P37268 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1618680 | 0.84 | PPARG (0.44) | PPARGPPARAPPARDCYP1A2CYP3A4 | |
| SCHEMBL9255616 | 0.81 | PPARG (0.43) | PPARGPPARAPPARDCYP1A2CYP3A4 | |
| SCHEMBL10547306 | 0.78 | ALDH1A1 (0.41) | PPARGPPARAPPARDCYP1A2CYP3A4 | |
| SCHEMBL11637275 | 0.75 | ALDH1A1 (0.43) | PPARGPPARAPPARDCYP1A2CYP3A4 | |
| SCHEMBL23867614 | 0.73 | PPARG (0.47) | PPARGPPARAPPARDCYP1A2CYP3A4 | |
| SCHEMBL7167780 | 0.73 | PPARG (0.41) | PPARGPPARAPPARDCYP1A2CYP3A4 | |
| SCHEMBL11383504 | 0.72 | PPARG (0.46) | PPARGPPARAPPARDCYP1A2CYP3A4 | |
| SCHEMBL27393596 | 0.72 | PPARG (0.46) | PPARGPPARAPPARDCYP1A2CYP3A4 | |
| SCHEMBL247466 | 0.72 | PPARA (0.68) | PPARGPPARAPPARDCYP1A2CYP3A4 | |
| SCHEMBL3707552 | 0.71 | PPARG (0.44) | PPARGPPARAPPARDCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5376683-A | Δ8- and Δ9-prostaglandin derivatives, process for their production and their pharmaceutical use | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-12-27 | — | — | US | disclosed |
| US-5235072-A | 2-OXABICYCLO(2,2,1)HEPTANE DERIVATIVES AND PHARMACEUTICAL | SCHERING AKTIENGSELLSCHAFT (DE) | 1993-08-10 | — | — | US | disclosed |