Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 3/20 | 0.31 |
| ▸ | CA4 | P22748 | 3/20 | 0.31 |
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA6 | P23280 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3357954 | 0.80 | MEN1 (0.38) | MEN1KMT2A | |
| SCHEMBL363341 | 0.77 | KDM4E (0.45) | KDM4EPKMHSD17B10LMNAMAPK1 | |
| SCHEMBL4735982 | 0.75 | KDM4E (0.44) | KDM4EPKMHSD17B10LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL28586799 | 0.75 | KDM4E (0.44) | KDM4EPKMHSD17B10LMNAMAPK1 | |
| SCHEMBL930667 | 0.73 | KDM4E (0.47) | KDM4EERN1MAPTMEN1KMT2A | |
| SCHEMBL25773828 | 0.73 | KDM4E (0.37) | KDM4ELMNAMAPK1MAPTMEN1 | |
| SCHEMBL30487328 | 0.73 | KDM4E (0.37) | KDM4ELMNAMAPK1MAPTMEN1 | |
| SCHEMBL10322145 | 0.71 | ERN1 (0.44) | KDM4EERN1HSD17B10MAPTMEN1 | |
| SCHEMBL11216824 | 0.71 | HSD17B10 (0.52) | KDM4EPKMHSD17B10LMNAMAPK1 | |
| SCHEMBL11933625 | 0.70 | ACHE (0.50) | KDM4EPKMERN1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002409-A1 | 5H-PYRROLO[3,4-£>]PYRAZIN-7-AMINE DERIVATIVES INHIBITORS OF BETA-SECRETASE | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002409-A1 | 5H-PYRROLO[3,4-£>]PYRAZIN-7-AMINE DERIVATIVES INHIBITORS OF BETA-SECRETASE | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |