Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25171978 | 0.76 | HTR2A (0.50) | NISCHCYP2D6HTR2AHTR3EHTR3B | |
| SCHEMBL8292046 | 0.74 | GSK3A (0.40) | CYP2D6HTR2ACYP1A2PRCPHTR2C | |
| SCHEMBL4718750 | 0.68 | RYR2 (0.42) | NISCHCYP2D6HTR2AHTR3EHTR3B | |
| SCHEMBL894789 | 0.68 | NISCH (0.57) | NISCHCYP2D6HTR2AHTR3EHTR3B | |
| SCHEMBL27953 | 0.67 | ALDH1A1 (0.59) | NISCHCYP1A2TSHRNFKB1HSD17B10 | |
| SCHEMBL25302086 | 0.67 | ALDH1A1 (0.59) | NISCHCYP1A2TSHRNFKB1HSD17B10 | |
| SCHEMBL29350007 | 0.67 | ALDH1A1 (0.59) | NISCHCYP1A2TSHRNFKB1HSD17B10 | |
| SCHEMBL9044714 | 0.67 | NISCH (0.47) | NISCHCYP2D6HTR2AHTR3EHTR3B | |
| SCHEMBL4765544 | 0.66 | NISCH (0.55) | NISCHCYP2D6HTR2AHTR3EHTR3B | |
| SCHEMBL5408922 | 0.66 | NISCH (0.39) | NISCHCYP1A2HTR1ATSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398413-A1 | \"3,4-dehydropiperidine derivatives having psychotropic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1990-11-22 | — | — | EP | claimed |
| US-5296497-A | 3,4-dehydropiperidine derivatives having psychotropic activity | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1994-03-22 | — | — | US | disclosed |
| EP-0398413-A1 | \"3,4-dehydropiperidine derivatives having psychotropic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1990-11-22 | — | — | EP | disclosed |