Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 11/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14085318 | 0.82 | NISCH (0.41) | HTR2AHTR2CHTR6NISCHHTR3E | |
| SCHEMBL9304715 | 0.76 | NISCH (0.42) | HTR2AHTR2CHTR2BHTR6NISCH | |
| SCHEMBL11134482 | 0.76 | HTR2A (0.53) | HTR2AHTR2CHTR2BHTR6HSD17B10 | |
| SCHEMBL27201538 | 0.75 | HTR2A (0.49) | HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL8959970 | 0.75 | HTR2A (0.59) | HTR2AHTR2CHTR2BHTR6NISCH | |
| Hydrochloric Acid SCHEMBL3691039 | 0.74 | HTR6 (0.49) | HTR2AHTR2CHTR2BHTR6NISCH | |
| Hydrochloric Acid SCHEMBL2855289 | 0.74 | HTR6 (0.49) | HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL7166811 | 0.74 | SLC6A3 (0.44) | NISCHCYP1A2HTR1ATSHRNFKB1 | |
| SCHEMBL31295140 | 0.73 | HTR2A (0.65) | HTR2AHTR2CHTR2BHTR6HTR1A | |
| SCHEMBL1681365 | 0.73 | SLC6A3 (0.46) | NISCHCYP1A2TSHRNFKB1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250032476-A1 | ALPHA-2A ADRENERGIC RECEPTOR MODULATORS AND USES THEREOF | UNIV CALIFORNIA (US) | 2025-01-30 | — | — | US | disclosed |
| EP-4426287-A1 | ALPHA-2A ADRENERGIC RECEPTOR MODULATORS AND USES THEREOF | The Regents of the University of California (US) | 2024-09-11 | — | — | EP | disclosed |
| WO-2023081800-A1 | ALPHA-2A ADRENERGIC RECEPTOR MODULATORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023081800-A1 | ALPHA-2A ADRENERGIC RECEPTOR MODULATORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250032476-A1 | ALPHA-2A ADRENERGIC RECEPTOR MODULATORS AND USES THEREOF | ADRA2A, ADRB2, ADRA2C | HTR2A 14/4885HTR2C 52/4885HTR2B 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.