SCHEMBL9305331

SCHEMBL9305331

OC(=S)CC(C(O)=S)c1nc2c(-c3ccccc3)cccc2o1

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TOP2A P11388 2/20 0.36
PIK3CD O00329 1/20 0.36
PIK3CA P42336 1/20 0.36
PIK3CB P42338 1/20 0.36
CNR2 P34972 3/20 0.32
LIPG Q9Y5X9 1/20 0.31
CTSA P10619 2/20 0.30
PDCD1 Q15116 1/20 0.30
CD274 Q9NZQ7 1/20 0.30
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
MAOB P27338 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9305342 0.90 TOP2A (0.39) TOP2APIK3CDPIK3CAPIK3CBCNR2
SCHEMBL9306229 0.82 DAGLA (0.39) PIK3CDPIK3CB
SCHEMBL8973078 0.80 IKBKE (0.32)
SCHEMBL8972323 0.79 NPC1 (0.42) ALDH1A1RAB9A
SCHEMBL9304105 0.79
SCHEMBL9733962 0.79
SCHEMBL9305328 0.79 TOP2A (0.40) TOP2APIK3CDPIK3CAPIK3CBCNR2
Ammonia Solution, Strong SCHEMBL10865670 0.78 RAB9A (0.41) ALDH1A1RAB9A
SCHEMBL10052156 0.78 TOP2A (0.41) TOP2APIK3CDPIK3CAPIK3CBKDM4E
SCHEMBL9306338 0.77 HSD17B10 (0.36) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5347008-A Thio(cyclo) alkanepolycarboxylic acids containing heterocyclic substituents CIBA-GEIGY CORPORATION (US) 1994-09-13 US disclosed
US-5152929-A Corrosion inhibitors for water systems CIBA-GEIGY CORPORATION (US) 1992-10-06 US disclosed
US-4612049-A BENZOTHI ZOLYL THIO-, BENZIMIDAZOLYLTHIO- OR BENZOXAZOLYLTHIO-SUBSTITUTED CARBOXY ACID CIBA-GEIGY CORPORATION (US) 1986-09-16 US disclosed